By Donald Huddler,Edward R. Zartler
Applied Biophysics for Drug Discovery is a advisor to new innovations and methods to opting for and characterizing small molecules in early drug discovery. Biophysical tools are reasserting their application in drug discovery and during a mix of the increase of fragment-based drug discovery and an elevated concentrate on extra nuanced characterisation of small molecule binding, those equipment are enjoying an expanding position in discovery campaigns.
This textual content emphasizes sensible issues for choosing and deploying middle biophysical strategy, together with yet no longer restricted to ITC, SPR, and either ligand-detected and protein-detected NMR.
Topics lined include:
• layout issues in biophysical-based lead screening
• Thermodynamic characterization of protein-compound interactions
• Characterizing goals and screening reagents with HDX-MS
• Microscale thermophoresis tools (MST)
• Screening with susceptible Affinity Chromatography
• easy methods to determine compound place of abode time
• 1D-NMR tools for hit identification
• Protein-based NMR tools for SAR development
• case reviews integrating a number of biophysical methods
This textual content is perfect for tutorial investigators and scientists making plans hit characterization campaigns or designing and optimizing screening strategies.
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Additional resources for Applied Biophysics for Drug Discovery
Applied Biophysics for Drug Discovery by Donald Huddler,Edward R. Zartler